2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N17929
    Doliroside A 93078-67-2
    Doliroside A is an Aβ42-binding agent with an IC50 of 26.57 μM for Aβ42. Doliroside A binds to Aβ42 nuclei and oligomers to form stable complexes, suppresses Aβ42 fibrillation, and redirects Aβ42 into off-pathway, amorphous oligomers. Doliroside A can be used for the research of alzheimer’s disease (ad).
    Doliroside A
  • HY-N17964
    Congmuyenoside I 1417579-26-0 98%
    Congmuyenoside I is a triterpenoid saponin. Congmuyenoside I mediates neuroprotective effects against H2O2-induced cellular damage. Congmuyenoside I can be used in the research of neurodegenerative diseases.
    Congmuyenoside I
  • HY-N17990
    Sexangularetin 3-sophoroside 114882-17-6 98%
    Sexangularetin 3-sophoroside is a PDK1 and Akt phosphorylation activator with neuroprotective properties. Sexangularetin 3-sophoroside restores phosphorylated GSK-3β protein levels. Sexangularetin 3-sophoroside acts as a ROS inhibitor and regulates mRNA expression of superoxide dismutase 1 and catalase. Sexangularetin 3-sophoroside can be used for the research of Parkinson’s disease.
    Sexangularetin 3-sophoroside
  • HY-N18014
    Naringenin 4',7-dimethyl ether 102101-05-3
    Naringenin 4',7-dimethyl ether, Naringenin (HY-N0100) derivative is an anti-seizure agent. Naringenin 4',7-dimethyl ether attenuates pentylenetetrazole-induced seizures in larval zebrafish and reduces seizures in the mouse 6-Hz psychomotor seizure model. Naringenin 4',7-dimethyl ether can be used for the research of epilepsy.
    Naringenin 4',7-dimethyl ether
  • HY-N18037
    Retinyl linoleate 631-89-0
    Retinyl linoleate is a retinyl ester. Retinyl linoleate is synthesized by microsomes from Retinoic acid (HY-14649)-treated cultured human keratinocytes.
    Retinyl linoleate
  • HY-N18059
    Spiradine A 19741-46-9
    Spiradine A (6-Hydroxyhetisan-11-one) is a C20 diterpenoid alkaloid present in the roots of Thalictrum sessile (Ranunculaceae), and is originally isolated from Spiraea japonica (Rosaceae). Spiradine A may possess anti-inflammatory and analgesic activities.
    Spiradine A
  • HY-N18076
    Nordracorubin 35290-22-3
    Nordracorubin is a flavonoid oligomer present in Daemonorops draco. Nordracorubin can be used in the research of Alzheimer's disease and cancer.
    Nordracorubin
  • HY-N18091
    Tovophyllin A 40738-44-1 98%
    Tovophyllin A is an orally active xanthonoid compound. Tovophyllin A exerts neuroprotective effects against Parkinson's disease by activating the Akt/GSK3β signaling pathway. Tovophyllin A protects mouse models of liver injury by activating Nrf2. Tovophyllin A exhibits protective anti-inflammatory activity in mouse models of acute lung injury. Tovophyllin A inhibits the activation of NF-κB and subsequent release of pro-inflammatory cytokines. Tovophyllin A reduces apoptotic cell death (Apoptosis). Tovophyllin A has antiplasmodial activity. Tovophyllin A shows cytotoxic activity against lung epithelial cancer cells and breast cancer cells. Tovophyllin A can be used in research related to Parkinson's disease, liver injury, acute lung injury, lung epithelial cancer, and breast cancer.
    Tovophyllin A
  • HY-N18124
    1-O-Tigloyl-1-O-debenzoylohchinal 122688-84-0 98%
    1-O-Tigloyl-1-O-debenzoylohchinal is an orally active limonoid-type triterpenoid anti-inflammatory and peripheral analgesic agent isolated from the fruits of Melia toosendan. 1-O-Tigloyl-1-O-debenzoylohchinal significantly inhibits acetic acid (HY-Y0319)-induced increase in vascular permeability, λ-Carrageenan (HY-N9470)-induced paw edema, and acetic acid-induced writhing response in mice. 1-O-Tigloyl-1-O-debenzoylohchinal shows no significant analgesic effect in the hot-plate test, and acts mainly on the peripheral rather than the central nervous system. 1-O-Tigloyl-1-O-debenzoylohchinal can be widely used in the research of acute or chronic inflammation, stomachache and other related diseases.
    1-O-Tigloyl-1-O-debenzoylohchinal
  • HY-N18155
    2-Hydroxy-6-oxo-1(10),7(11)-germacradien-12,8-olide 1042109-84-1
    2-Hydroxy-6-oxo-1(10),7(11)-germacradien-12,8-olide ((1(10)E,2α,4β,8α)-form,2-Meether) is a furanosesquiterpenoid neuroprotective agent that exhibits neuroprotective effect against MPP+-induced neuronal cell death. 2-Hydroxy-6-oxo-1(10),7(11)-germacradien-12,8-olide can be used for the research of parkinson's disease.
    2-Hydroxy-6-oxo-1(10),7(11)-germacradien-12,8-olide
  • HY-N18211
    1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin 1613615-07-8 98%
    1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin is a nerve growth factor-enhanced limonoid. 1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin enhances nerve growth factor-mediated neurite outgrowth in PC12 cells. 1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin enhances nerve growth factor-mediated neurite outgrowth.
    1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin
  • HY-N18261
    8-Geranyloxy-5-methoxypsoralen 17182-52-4
    8-geranyloxy-5-methoxypsoralen is a BACE1 inhibitor with an IC50 of 11.1 μM. 8-geranyloxy-5-methoxypsoralen potently inhibits BACE1 activity. 8-Geranyloxy-5-methoxypsoralen can be used for the research of Alzheimer's disease.
    8-Geranyloxy-5-methoxypsoralen
  • HY-N18279
    Bulbocapnine 298-45-3 98%
    Bulbocapnine is an aporphine isoquinoline alkaloid that exerts antagonistic effects on dopamine Receptor) and α-adrenergic receptors, as well as anti-peroxidative effects. The Ki value of bulbocapnine for tyrosine hydroxylase (TH) is 0.20 mM. Bulbocapnine reduces intracellular dopamine content, inhibits TH activity, and decreases Ca2+ concentration. Bulbocapnine antagonizes the dose-dependent inhibitory effect of dopamine on the heart rate acceleration induced by stimulating the postganglionic fibers of the right cardiac accelerator nerve.
    Bulbocapnine
  • HY-N18289
    8-Hydroxydihydrochelerythrine 4070-42-2 98%
    8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC50=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease.
    8-Hydroxydihydrochelerythrine
  • HY-N18341
    Ginkgolide M 15291-78-8 98%
    Ginkgolide M (GM) is a ginkgolide that can be isolated from Ginkgo biloba. Ginkgolide M acts as an inhibitor of ligand-gated ion channels in the central nervous system and exerts inhibitory effects on the GABAA receptor. Ginkgolide M can be used for the research of neurodegenerative diseases such as Alzheimer's disease.
    Ginkgolide M
  • HY-N18367
    Lemairamin 29946-61-0 98%
    Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity.
    Lemairamin
  • HY-N18386
    Altissimacoumarin F 1384897-64-6
    Altissimacoumarin F (Compound 4) is a terpenylated coumarin. Altissimacoumarin F can be isolated from the stem bark of Ailanthus altissima. Altissimacoumarin F enhances SIRT1 activity, decreases p53 transcriptional activity. Altissimacoumarin F can be used for the research of age-related disorders.
    Altissimacoumarin F
  • HY-N18471
    5,7-Dihydroxytryptamine 31363-74-3 98%
    5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons.
    5,7-Dihydroxytryptamine
  • HY-N18680
    Melissa officinalis extract 84082-61-1
    Melissa officinalis extract is rich in various bioactive compounds, such as citronellol, geraniol, glycosides, caffeic acid derivatives, flavonoids, and triterpenoids. Melissa officinalis extract can be used in research on conditions such as nervous tension, anxiety, insomnia, and menstrual disorders.
    Melissa officinalis extract
  • HY-N18690
    Mucuna pruriens extract 90064-10-1
    Mucuna pruriens extract, derived from the seeds of the Mucuna pruriens plant, the primary active compound in Mucuna pruriens is L-dopa (levodopa), a precursor to the neurotransmitter dopamine, which contributes to its neuroprotective and mood-enhancing effects.
    Mucuna pruriens extract
Cat. No. Product Name / Synonyms Application Reactivity